Parkinson’s

Parkinson’s

Signs and Symptoms

Tremors

Alzheimer-1

Rigidity

Slowness

Memory Loss at late stage

Alzheimer-1

Delusions

Behavior

Anxiety

Hallucinations

No pain

Human and Financial Cost. No long term Effective Treatment

250,000 (UK) and 10 million (worldwide) are suffering from Parkinson’s disease. In 2020 the cost was $52 billion to the global economy. By 2030 it is estimated there will be over 13 million sufferers world-wide.

Although Parkinson’s disease is often diagnosed in people 60 years old and older, it starts earlier with subtle neurological changes occurring years or even decades before symptoms appear. Diagnosis is based on symptoms, by which time irreversible brain damage has occurred.

The three main symptoms of Parkinson’s are involuntary shaking of particular parts of the body (tremor), slow movement and stiff and inflexible muscles. People can also experience depression and anxiety, co-ordination problems, loss of smell, insomnia and memory problems. At advanced stages of the disease is it also common to develop dementia.

α-synuclein is implicated in Parkinson’s disease. The protein misfolds and forms aggregates that build up in neurons in the brain called Lewy Bodies.

One of PharmaKure’s drugs is an antidepressant and a similar drug has been shown to prevent the aggregation of α-synuclein. They anticipates that their screening program will identify another off-label compounds that can break them down these toxic aggregates.

PharmaKure will have an emphasis on early-stage disease detection using our internal, unique biomarker profiling system PARKmetrix®. Early results look encouraging.

Our lead candidate for Parkinson’s

PK081

a combination of 2 off-label drugs, which break down aggregates of α-synuclein and prevent new aggregates from forming.

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