Director and Professor of Biochemistry in the Division of Neuroscience & Experimental Psychology, University of Manchester
Alzheimer’s Disease is caused by a small protein called amyloid-ß clumping together, becoming toxic and killing brain cells. We design and discover new drugs to reduce the toxicity of amyloid-ß and investigate how amyloid-ß affects cells. Drug discovery typically requires the identification of protein targets capable of eliciting a desired biological response. We have studied drug target proteins to identify properties that are desirable in human drug targets for different diseases. Machine learning is applied to find new genes that are involved in cancer or in mouse development. We use vibrational spectroscopy to characterise protein structure, focussing on antibodies, in particular.